Molecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins

TitleMolecular mechanisms of aqueous boundary lubrication by mucinous glycoproteins
Publication TypeJournal Article
Year of Publication2010
AuthorsJM Coles, DP Chang, and S Zauscher
JournalCurrent Opinion in Colloid & Interface Science
Start Page406
Pagination406 - 416
Date Published12/2010

Mucins have long been recognized as instrumental to biolubrication but the molecular details of their lubrication mechanisms have only been explored relatively recently. The glycoprotein PRG4, also known as lubricin, shares many features with mucins and appears to lubricate through similar mechanisms. A number of studies have contributed to a more in-depth understanding of mucin adsorption and layer formation on surfaces and the mechanisms by which these layers lubricate. Although mucinous glycoproteins differ in their aggregation properties, their adsorption behaviors on surfaces, and in their ability to reduce friction, they share important similarities favorable for lubrication. They are highly hydrated, they adsorb strongly to a broad range of surfaces, and the layers they form are both sterically and electrostatically repulsive, all attributes thought to contribute to boundary lubrication. They also hydrophilize hydrophobic surfaces, promoting the formation of aqueous fluid films that can lower friction at already relatively low sliding speeds. In this paper we briefly review current knowledge of mucin adsorption and lubrication, with a focus on recent advances. © 2010 Elsevier Ltd.

Short TitleCurrent Opinion in Colloid & Interface Science