Title | Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | R Gu, J Lamas, SK Rastogi, X Li, W Brittain, and S Zauscher |
Journal | Colloids and Surfaces. B, Biointerfaces |
Volume | 135 |
Start Page | 126 |
Pagination | 126 - 132 |
Date Published | 11/2015 |
Abstract | We demonstrate the reversible micellar aggregation of a DNA-azobenzene conjugate in aqueous conditions, in which the photoisomerization of the initially apolar trans-azobenzene moiety to the polar cis isomer causes disassembly of the aggregates. The molecular basis for this phenomena is a change in the hydrophobic/hydrophilic balance of the conjugate as the more polar cis azobenzene isomer is formed upon exposure to 365 nm irradiation. The conjugates were prepared by copper-free Click chemistry between an azide-modified, 53-base ssDNA and a cyclooctyne derivative of azobenzene. The photocontrolled aggregation of the conjugate was studied by dynamic light scattering and atomic force microscopy. The reversible micellar aggregation for a DNA-azobenzene conjugate has not been previously reported and holds promise for photocontrolled drug delivery applications. |
DOI | 10.1016/j.colsurfb.2015.07.010 |
Short Title | Colloids and Surfaces. B, Biointerfaces |
