October 11, 2023
Novel strategies allow for both spatial and temporal control of polynucleotide brush modification on DNA origami through activation and regeneration of initiation sites using restriction enzymes in combination with TdT-catalyzed enzymatic polymerization. Spatiotemporal control of brush growth provides access to “smart” functionalized DNA architectures with potential applications ranging from drug delivery to supracolloidal assembly.
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202311727